IMO, he cannot in his current state. the craze is missing. back in 2007 he almost got HGOTY and ATG with Welcome and if the movie hadn't clashed, it would have achieved those things. the opening was also huge. but the kind of movies he's doing today either don't have that scope, or they aren't that good.
I am glad that he is apparently trying to get back into that massy zone. Robot 2 is coming soon, he has signed a comedy remake called Lord of Lungi (which could be entertaining but the director is awful), he's been reported to be in talks with Priyadarshan and Hera Pheri 3 could also start soon.
If he does these type of movies and gets back to that level he was in 2007, then maybe. But I don't think it will happen.