Yes...possible....
For Best Actor/Actress (Popular) ----
U don;t need to be a super star
U don;t need to do any good acting
U don;t need to do any film which is highest grosser or in Top 10 for that year
Only requirement is that U just need to do one film
and rest voting process will take care
And for any reason u r not the winner of the voting process then also there are slight chances of winning it - just perform on the stage for free/less fees.....